Is Thumbs.db A virus , How To remove Thumbs.db

You can prvent the formation of thumbs.db just by Disabling Thumbnails with a Registry Hack

Open the registry (regedit.exe) from the Run command and navigate to the following
key:

HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\

Explorer\Advanced

Double click on the DisableThumbnailCache key in the right-hand pane and change
the value to 1. If the key is not there, go to Edit, then New and choose DWORD

Value to create one with the same name.

Close the Registry and reboot your computer for the changes to take effect.
If you have a lot of folders with lots of pictures, it would be best to disable the
thumbnail cache because each picture in the cache is about 2KB, meaning a 1000
pictures in one folder would result in a cache of 2MBs!